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Ultra-high-field 7T MRI reveals changes in human medial temporal lobe volume in female adults during menstrual cycle by Rachel G. Zsido; Angharad N. Williams; Claudia Barth; Bianca Serio; Luisa Kurth; Toralf Mildner; Robert Trampel; Frauke Beyer; A. Veronica Witte; Arno Villringer; Julia Sacher is a Psychology article available to read on EtoBox.

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## Abstract Ovarian hormones have substantial effects on the brain, and early menopause has been associated with increased risk of accelerated brain aging and dementia later in life. However, the impact of ovarian hormone fluctuations on brain structure earlier in life is less understood. Here we show that ovarian hormone fluctuations shape structural brain plasticity during the reproductive years. We use longitudinal ultra-high field neuroimaging across the menstrual cycle to map the morphology of medial temporal lobe subregions in 27 participants. Controlling for water content and blood flow, our findings reveal positive associations between estradiol and parahippocampal cortex volume, progesterone and subiculum and perirhinal area 35 volumes, and an estradiol\*progesterone interaction with CA1 volume. This research offers a blueprint for future studies on the shared dynamics of the brain and ovarian function and a fundamental stepping stone towards developing sex-specific strategies to improve brain health and mental health.

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Author

Rachel G. Zsido; Angharad N. Williams; Claudia Barth; Bianca Serio; Luisa Kurth; Toralf Mildner; Robert Trampel; Frauke Beyer; A. Veronica Witte; Arno Villringer; Julia Sacher

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Psychology (Social Sciences)