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FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals by Kang, Hyo Jung; Yoon, Sujung; Lee, Suji; Choi, Koeul; Seol, Sihwan; Park, Shinwon; Namgung, Eun; Kim, Tammy D.; Chung, Yong-An; Kim, Jungyoon; Han, Jung-Soo; Lyoo, In Kyoon is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals about?

The epigenetic regulation of microRNA (miRNA) expression related to the FK506-binding protein 5 (FKBP5) gene may contribute to the risk of stress-related disorders such as posttraumatic stress disorder (PTSD). Here, we identified candidate miRNAs derived from FKBP5 knockout mice as a potential diagnostic biomarker of PTSD. Using a translational approach, candidate miRNAs found to alter in expression within the medial prefrontal cortex of FKBP5 knockout mice were selected. Each candidate miRNA was examined in the serum of 48 recently traumatized individuals with PTSD and 47 healthy individuals. Multimodal imaging was also conducted to identify the neural correlates for the expression of candidate exosomal miRNAs in response to trauma exposure. Differential miRNA expression was found according to PTSD diagnosis in two composite marker groups. The differential miRNA expression between the composite marker groups contributed to PTSD symptom severity, which may be explained by differential recruitment of prefrontolimbic activity in brain imaging. The present study reveals that a set of circulating exosomal miRNAs showing altered expression in FKBP5 knockout mice play a potential role as

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Author

Kang, Hyo Jung; Yoon, Sujung; Lee, Suji; Choi, Koeul; Seol, Sihwan; Park, Shinwon; Namgung, Eun; Kim, Tammy D.; Chung, Yong-An; Kim, Jungyoon; Han, Jung-Soo; Lyoo, In Kyoon

Publisher

Springer Science and Business Media LLC; London: Nature Publishing Group; [London]: Springer Nature; Nature Publishing Group; Society for Mining, Metallurgy and Exploration Inc.; Research Square; Springer Nature; Island Press (ISSN 2045-2322)

Published

2020

Language

EN

ISBN

9784159802067

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)