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1) Serum levels of type IV collagen (IV-C) and laminin (LM) increased with progression of chronic liver disease from chronic inactive hepatitis to chronic active hepatitis to liver cirrhosis. 2) Matrix metalloproteinase (MMP)-2 and MMP-3 levels, which can degrade extracellular matrix proteins including IV-C, also increased with disease progression, especially in liver cirrhosis. 3) Both tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 levels were markedly higher in liver cirrhosis compared to l

Author

hobanoh

Language

EN