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Toxicity Measurement of Orthopedic Implant Alloy Degradation Products Using a Bioluminescent Bacterial Assay by Melissa G. Shettlemore; Kirk J. Bundy is a Medicine article available to read on EtoBox.

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The toxicity of aqueous metal solutions representative of ionic degradation products from orthopedic implant alloys was determined using a bacterial bioluminescence assay, Microtox. The toxicity of forms of the individual elements released from ASTM F75 Co-Cr-Mo (Co-Cr-Mo), F138 316L stainless steel (316L), and F136 Ti-6Al-4V (Ti-6Al-4V) was first determined, and a mathematical model was developed to predict the toxicity of mixtures of these ions. Aqueous metal solutions were then mixed according to the proportions of the ions found in these alloys, and their toxicity was measured with Microtox. Mixture behavior was classified as synergistic, antagonistic, or additive by comparing measured toxicity to predicted toxicity. Since relating these tests to actual implant corrosion processes can be confounded by selective leaching, the predicted and measured toxicity of aqueous metal solutions mixed according to proportions representative of selective leaching were next determined, and the mixture behaviors were classified as be-fore. The most toxic individual alloying elements were found to be hexavalent Cr, Ni, and Co, in that order: a finding in accord with prior biocompatibility resea

Who reads Toxicity Measurement of Orthopedic Implant Alloy Degradation Products Using a Bioluminescent Bacterial Assay?

Author

Melissa G. Shettlemore; Kirk J. Bundy

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Heterocorporation; Wiley (ISSN 0021-9304)

Published

1999

Language

EN

Field

Medicine (Health Sciences)