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The Role of Endolysosomal Trafficking in Anticancer Drug Resistance by Noor A. Hussein; Saloni Malla; Mariah A. Pasternak; David Terrero; Noah G. Brown; Charles R. Ashby; Yehuda G. Assaraf; Zhe-Sheng Chen; Amit K. Tiwari is a Medicine article available to read on EtoBox.

What is The Role of Endolysosomal Trafficking in Anticancer Drug Resistance about?

Multidrug resistance (MDR) remains a major obstacle towards curative treatment of cancer. Despite considerable progress in delineating the basis of intrinsic and acquired MDR, the underlying molecular mechanisms remain to be elucidated. Emerging evidences suggest that dysregulation in endolysosomal compartments is involved in mediating MDR through multiple mechanisms, such as alterations in endosomes, lysosomes and autophagosomes, that traffic and biodegrade the molecular cargo through macropinocytosis, autophagy and endocytosis. For example, altered lysosomal pH, in combination with transcription factor EB (TFEB)-mediated lysosomal biogenesis, increases the sequestration of hydrophobic anti-cancer drugs that are weak bases, thereby producing an insufficient and off-target accumulation of anti-cancer drugs in MDR cancer cells. Thus, the use of well-tolerated, alkalinizing compounds that selectively block Vacuolar H+-ATPase (V-ATPase) may be an important strategy to overcome MDR in cancer cells and increase chemotherapeutic efficacy. Other mechanisms of endolysosomal-mediated drug resistance include increases in the expression of lysosomal proteases and cathepsins that are involved

Who reads The Role of Endolysosomal Trafficking in Anticancer Drug Resistance?

Author

Noor A. Hussein; Saloni Malla; Mariah A. Pasternak; David Terrero; Noah G. Brown; Charles R. Ashby; Yehuda G. Assaraf; Zhe-Sheng Chen; Amit K. Tiwari

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)