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Physical Property Scaling Relationships for Polyelectrolyte Complex Micelles by Alexander E. Marras; Trinity R. Campagna; Jeffrey R. Vieregg; Matthew V. Tirrell is a Materials Science article available to read on EtoBox.

What is Physical Property Scaling Relationships for Polyelectrolyte Complex Micelles about?

Polyelectrolyte complex micelles (PCMs) are self-assembled nanoparticles formed by associative phase separation of hydrophilic neutralcharged block copolymers and polyelectrolytes and are effective in the delivery of hydrophilic payloads. Their attractive features include an ability to tune physical attributes such as core and corona size, particle shape, and stability, all of which are strongly dependent on the size and chemical structure of each polymer block. Previous studies have provided qualitative examples of these dependencies, but no quantitative structure-property relations have been developed to allow rational design of PCMs. Developing such design rules is crucial for applications and provides a greater understanding of the physics of polyelectrolyte assembly. In this work, we use small-angle X-ray scattering, electron microscopy, and light scattering to determine the scaling behavior of physical micelle parameters for commonly used, biologically relevant polyelectrolytes. As an example, for PCMs constructed from hydrophilic neutral-polyelectrolyte block copolymers and oppositely charged homopolymers, we find that the size of the PCM core increases strongly with the cha

Who reads Physical Property Scaling Relationships for Polyelectrolyte Complex Micelles?

Author

Alexander E. Marras; Trinity R. Campagna; Jeffrey R. Vieregg; Matthew V. Tirrell

Publisher

American Chemical Society (ACS)

Published

2021

Language

EN

Field

Materials Science (Physical Sciences)