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What is Hydrodynamics in Paddle Dissolution Testing about?

This document summarizes a study that used computational fluid dynamics (CFD) modeling to investigate how the hydrodynamics in a USP paddle dissolution apparatus change with different paddle rotational speeds. The CFD model was used to simulate paddle speeds of 25, 50, 100, and 150 rpm. It found that maximum fluid velocities in the vessel increased linearly with rotational speed. Mixing patterns also varied significantly between speeds. The approximate time to achieve complete mixing ranged from 2-5 seconds

Author

abhijit_gothoskar6039

Language

EN