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Collagen I membranes for tendon repair: Effect of collagen fiber orientation on cell behavior by Antonio Gigante; Eugenio Cesari; Alberto Busilacchi; Sandra Manzotti; Kyriaki Kyriakidou; Francesco Greco; Roberto Di Primio; Monica Mattioli-Belmonte is a Medicine article available to read on EtoBox.

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## Abstract Tendons have poor spontaneous regenerative capabilities, and complete regeneration is never achieved despite intensive remodeling. In this in vitro study, we characterized two multilamellar collagen I membranes differing in the arrangement of collagen fiber deposition (oriented vs. nonoriented) and compared their mechanical properties. Human dermal fibroblasts and tenocytes were seeded on the two membranes to evaluate the effect of fiber orientation on cell viability and cytoskeletal organization. Results demonstrate that the multilamellar collagen I membrane with oriented fibers has the better mechanical properties and affords optimum cell proliferation and adhesion. Its fiber arrangement provides an instructive pattern for cell growth and may serve to guide the alignment of cells migrating from the ends of a crushed or frayed tendon to obtain a strong, correctly structured tendon, thus providing a viable clinical option for tendon repair. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27: 826–832, 2009

Who reads Collagen I membranes for tendon repair: Effect of collagen fiber orientation on cell behavior?

Author

Antonio Gigante; Eugenio Cesari; Alberto Busilacchi; Sandra Manzotti; Kyriaki Kyriakidou; Francesco Greco; Roberto Di Primio; Monica Mattioli-Belmonte

Publisher

Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0736-0266)

Published

2009

Language

EN

Field

Medicine (Health Sciences)