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Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors by Song Jin; Jung Sun Kim; Sai-Peng Sim; Angela Liu; Daniel S. Pilch; Leroy F. Liu; Edmond J. LaVoie is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors about?
AbstractÐA series of 2 H -heterocyclic derivatives of 5-phenyl-2,5 H -1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. Topo I poisoning activity was associated with 2 H -derivatives that possessed a hydrogen atom capable of hydrogen bond formation, suggesting that the interatomic distances between such hydrogen atoms and the heteroatoms on the adjacent benzimidazole in ̄uence activity.
Who reads Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Song Jin; Jung Sun Kim; Sai-Peng Sim; Angela Liu; Daniel S. Pilch; Leroy F. Liu; Edmond J. LaVoie
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2000
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)