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Experimental and molecular dynamics simulation study on the delivery of some common drugs by ZIF‐67, ZIF‐90, and ZIF‐8 zeolitic imidazolate frameworks by Xiaodong Sun; Maryam Keywanlu; Reza Tayebee is a Chemistry article available to read on EtoBox.

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## Abstract Anti‐seizures have been frequently used for a long time. Most of these antiepileptic drugs, which are used on a daily basis, are central nervous system depressants, and their excessive use damages the respiratory system. Therefore, in order to achieve the desired therapeutic goals, avoiding side effects and drug interactions, it is very important to use targeted medications. Among the metal–organic frameworks (MOFs), ZIF nanoparticles have several advantages such as smooth capillary flow and the slow release of drugs, circulating and preventing increased drug concentrations in plasma. Gabapentin, levetiracetam, phenytoin, and valproate are effective drugs in the treatment of epilepsy. In this investigation, the zeolitic imidazolate frameworks ZIF‐67, ZIF‐90, and ZIF‐8 are used as carriers for the above drugs, and their loading processes are evaluated. Among these MOFs, the highest loading values are attained in the case of ZIF‐8. Therefore, the latter MOF is synthesized via a new simple method and characterized by X‐ray diffraction (XRD), Fourier transform infrared (FT‐IR), scanning electron microscopy (SEM), and X‐ray photoelectron spectroscopy (XPS) techniques. Also,

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Author

Xiaodong Sun; Maryam Keywanlu; Reza Tayebee

Publisher

Wiley

Published

2021

Language

EN

Field

Chemistry (Physical Sciences)