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Longitudinal assessment of immunological status and rate of immune recovery following treatment in children with ALL by Sofia Kosmidis; Margarita Baka; Despina Bouhoutsou; Dimitrios Doganis; Constantina Kallergi; Nikolaos Douladiris; Apostolos Pourtsidis; Maria Varvoutsi; Fotini Saxoni‐Papageorgiou; Helen Vasilatou‐Kosmidis is a Medicine article available to read on EtoBox.
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## Abstract ## Background We prospectively evaluated the immunological status, immune recovery and risk of infection in pediatric ALL patients treated on the BFM 95 protocol. ## Procedure Humoral and cellular immunity were evaluated in 72 children with ALL at the end of intensive therapy and values were compared to those at the completion of therapy and 6‐monthly. Parameters investigated included lymphocyte subpopulation by flow cytometry, immunoglobulin levels by nephelometry, antibody titers to previous immunizations and delayed hypersensitivity with skin testing. Immune responses were correlated to duration of therapy, CNS radiotherapy, age and sex. ## Results Humoral immunity was severely depressed by the end of intensive therapy with low immunoglobulin levels and CD19, improved after therapy cessation. Cellular immune responses were normal at the end of intensive treatment but declined significantly by the end of therapy and both CD4 and CD8 remained low at later evaluation points whereas CD4/CD8 ratio was increasing. Duration of therapy and CNS radiotherapy did not affect the rate of immune recovery whereas female had higher CD19, CD45RO, and IgM and children >7 years had hig
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- Author
- Sofia Kosmidis; Margarita Baka; Despina Bouhoutsou; Dimitrios Doganis; Constantina Kallergi; Nikolaos Douladiris; Apostolos Pourtsidis; Maria Varvoutsi; Fotini Saxoni‐Papageorgiou; Helen Vasilatou‐Kosmidis
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)