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551 Atopic dermatitis in childhood and academic performance by R. Iskandar; A. Mailhac; A. Mulick; C. Vestergaard; M.S. Deleuran; K. Abuabara; S.A. Schmidt; S.M. Langan is a Medicine article available to read on EtoBox.
What is 551 Atopic dermatitis in childhood and academic performance about?
Background: Alopecia areata (AA) is the most common type of non-scarring inflammatory alopecia. Objectives: To determine which immune and metabolic pathways are disregulated by circulating miRNAs in patients with alopecia areata (AA). Methods: Disease status was classified as mild/moderate (<50% involvement and 1 yr, 50% SALT, AT or AU). We interrogated 754 miRNAs on 26 naı ̈ve patients and 5 controls using RT-PCR OpenArray technology. Pathway enrichment and drug repurposing analyses were carried out with the GeneCodis and CMaps LINCS, respectively. Results: We identified 19 downregulated miRNAs in patients with severe AA vs mild/moderate and controls, showing an enrichment of pathways related to the immune system (antigen processing and presentation, cytokines, TCR regulation, Th1/Th2, IL-1, IL-4, IL-13), cell cycle, DNA damage repair, cellular response to stress, and post-translational modification of proteins. Some of the specific pathways overrepresented were p53, GFR, NOTCH1, PIP3/AKT, FGFR1, and PDGFR. Finally, 39 drugs potentially capable of reversing this state of dysregulation were predicted, being JAK kinase inhibitors the most important group and, to a lesser extent,
Who reads 551 Atopic dermatitis in childhood and academic performance?
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- Author
- R. Iskandar; A. Mailhac; A. Mulick; C. Vestergaard; M.S. Deleuran; K. Abuabara; S.A. Schmidt; S.M. Langan
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)