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Albiglutide in patients with type 2 diabetes and heart failure: a post‐hoc analysis from Harmony Outcomes by João Pedro Ferreira; Abhinav Sharma; Francisco Vasques‐Nóvoa; António Angélico‐Gonçalves; Ana Rita Leite; Marta Borges‐Canha; Davide Carvalho; Milton Packer; Faiez Zannad; Adelino Leite‐Moreira; João Sérgio Neves is a Medicine article available to read on EtoBox.

What is Albiglutide in patients with type 2 diabetes and heart failure: a post‐hoc analysis from Harmony Outcomes about?

## Abstract ## Aim Glucagon‐like peptide‐1 receptor agonists (GLP1‐RA) improve cardiovascular outcomes in patients with type 2 diabetes (T2D). However, some studies suggest that their effects in patients with heart failure (HF) may be attenuated. We aimed to explore the effects of the GLP1‐RA albiglutide on HF outcomes in patients with and without HF history enrolled in the Harmony Outcomes trial. ## Methods and results Harmony Outcomes enrolled patients with T2D and cardiovascular disease randomized to either albiglutide or placebo over a median follow‐up of 1.6 years. A total of 9462 patients were included, of whom 1922 (20%) had HF history. Patients with HF had more cardiovascular comorbidities, poorer renal function, and had a three to four‐fold higher risk of HF events compared to patients without HF. Compared to placebo, the effect of albiglutide on the composite of cardiovascular death or HF hospitalization was more pronounced among patients without HF (hazard ratio [HR] 0.73, 95% confidence interval [CI] 0.56–0.95) than in patients with HF (HR 1.06, 95% CI 0.79–1.43) (interaction p = 0.062). A similar pattern was observed for HF hospitalizations (interaction p = 0.025). The

Who reads Albiglutide in patients with type 2 diabetes and heart failure: a post‐hoc analysis from Harmony Outcomes?

Author

João Pedro Ferreira; Abhinav Sharma; Francisco Vasques‐Nóvoa; António Angélico‐Gonçalves; Ana Rita Leite; Marta Borges‐Canha; Davide Carvalho; Milton Packer; Faiez Zannad; Adelino Leite‐Moreira; João Sérgio Neves

Publisher

Wiley

Published

2022

Language

EN

Field

Medicine (Health Sciences)