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Expression of the matrix Gla protein in urogenital malignancies by Eleni N. Levedakou; Torsten G. Strohmeyer; Peter J. Effert; Edison T. Liu is a Medicine article available to read on EtoBox.

What is Expression of the matrix Gla protein in urogenital malignancies about?

Matrix Gla protein (MGP), is a vitamin-K-dependent protein which is synthesized in a variety of tissues such as lung, heart, kidney, cartilage and bone. The function of MGP in these tissues is unclear. We have previously reported elevated MGP mRNA levels in a breast-cancer cell line, 600PE1, as compared to normal breast epithelium. Here we describe high MGP expression in primary renal-cell carcinomas, prostate carcinomas and testicular germ-cell tumors, as determined by Northern analysis. MGP was over-expressed in 21 out of 28 patients with renal-cell carcinoma, and in I 6 out of 29 patients with testicular germ-cell tumors, as compared to matched normal tissues. For the renal-cell carcinomas, a statistically significant inverse correlation was observed between the level of MGP expression and tumor size, lymph-node metastasis and tumor grade. MGP was also highly expressed in 13 primary prostatic carcinomas as compared to prostate cell lines derived from metastatic tumors, and to lymph-node metastasis. Our findings indicate that the loss of MGP expression may be associated with tumor progression and metastasis.

Who reads Expression of the matrix Gla protein in urogenital malignancies?

Author

Eleni N. Levedakou; Torsten G. Strohmeyer; Peter J. Effert; Edison T. Liu

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1992

Language

EN

Field

Medicine (Health Sciences)