Can I read Fine‐tuning Dynamic Cross–linking for Enhanced 3D Bioprinting of Hyaluronic Acid Hydrogels on EtoBox?

Fine‐tuning Dynamic Cross–linking for Enhanced 3D Bioprinting of Hyaluronic Acid Hydrogels by Shima Tavakoli; Nithiyanandan Krishnan; Hamidreza Mokhtari; Oommen P. Oommen; Oommen P. Varghese is a Engineering article available to read on EtoBox.

What is Fine‐tuning Dynamic Cross–linking for Enhanced 3D Bioprinting of Hyaluronic Acid Hydrogels about?

## Abstract 3D bioprinting of stem cells shows promise for medical applications, but the development of an efficient bioink remains a challenge. Recently, the emergence of dynamically cross–linked hydrogels has advanced this field to obtain self‐healing materials. However, more advanced bioinks are needed that display optimum gelling kinetics, viscoelasticity, shear‐thinning property, structural fidelity, and hold the printed structures sufficiently long enough that allow maturation of the new tissue. Here, a novel extracellular matrix‐based bioink for human mesenchymal stem cells (hMSCs) is presented. Hyaluronic acid (HA) is modified with cysteine and aldehyde functional groups, creating hydrogels with dual cross–linking of disulfide and thiazolidine products. The investigation demonstrates that this cross–linking significantly improves hydrogel stability and biological properties. The bioink exhibits fast gelation kinetics, shear‐thinning, shape‐maintaining properties, high cell survival after printing with >2‐fold increase in stemness marker (OCT3/4 and NANOG), and supports cell proliferation and migration. Disulfide cross–linking contributes to self‐healing and cell migration,

Who reads Fine‐tuning Dynamic Cross–linking for Enhanced 3D Bioprinting of Hyaluronic Acid Hydrogels?

Author

Shima Tavakoli; Nithiyanandan Krishnan; Hamidreza Mokhtari; Oommen P. Oommen; Oommen P. Varghese

Publisher

Wiley

Published

2023

Field

Engineering (Physical Sciences)