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Sulindac and its metabolites inhibit invasion of glioblastoma cells via down‐regulation of Akt/PKB and MMP‐2 by Hyung‐Chahn Lee; In‐Chul Park; Myung‐Jin Park; Sungkwan An; Sang‐Hyeok Woo; Hyeon‐Ok Jin; Hee Yong Chung; Su‐Jae Lee; Ho‐Shin Gwak; Young‐Jun Hong; Doo‐Hyun Yoo; Chang‐Hun Rhee; Seok‐Il Hong is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Sulindac and its metabolites inhibit invasion of glioblastoma cells via down‐regulation of Akt/PKB and MMP‐2 about?
## Abstract Non‐steroidal anti‐inflammatory drug (NSAID), sulindac has chemopreventive and anti‐tumorigenic properties, however, the molecular mechanism of this inhibitory action has not been clearly defined. The Akt/protein kinase B, serine/threonine kinase is well known as an important mediator of many cell survival signaling pathways. In the present study, we demonstrate that down‐regulation of Akt is a major effect of anti‐invasiveness property of sulindac and its metabolites in glioblastoma cells. Myristoylated Akt (MyrAkt) transfected U87MG glioblastoma cells showed increase invasiveness, whereas DN‐Akt transfected cells showed decrease invasiveness indicating that Akt potently promoted glioblastoma cell invasion. MMP‐2 promoter and enzyme activity were up‐regulated in Akt kinase activity dependent manner. Sulindac and its metabolites down‐regulated Akt phosphorylation, inhibited MMP‐2 production, and significantly inhibited invasiveness of human glioblastoma cells. In addition, sulindac and LY294002, a selective inhibitor of phosphoinositide 3‐kinase (PI3K), synergistically inhibited the invasion of glioblastoma cells. Furthermore, only celecoxib showed Akt phosphorylation r
Who reads Sulindac and its metabolites inhibit invasion of glioblastoma cells via down‐regulation of Akt/PKB and MMP‐2?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Hyung‐Chahn Lee; In‐Chul Park; Myung‐Jin Park; Sungkwan An; Sang‐Hyeok Woo; Hyeon‐Ok Jin; Hee Yong Chung; Su‐Jae Lee; Ho‐Shin Gwak; Young‐Jun Hong; Doo‐Hyun Yoo; Chang‐Hun Rhee; Seok‐Il Hong
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)
- Published
- 2004
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)