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Mast Cell Tryptase Stimulates DLD-1 Carcinoma Through Prostaglandin- and MAP Kinase-Dependent Manners by Masanori Yoshii; Atsushi Jikuhara; Shuji Mori; Hiromi Iwagaki; Hideo K. Takahashi; Masahiro Nishibori; Noriaki Tanaka is a Medicine article available to read on EtoBox.
What is Mast Cell Tryptase Stimulates DLD-1 Carcinoma Through Prostaglandin- and MAP Kinase-Dependent Manners about?
We found that striptease-positive mast cells were abundant in the invasive front of human colon adenocarcinoma by examining 30 cases. Because tryptase has been suggested to be the agonist proteinase for protease-activated receptor-2 (PAR-2), we investigated the effects of stimulation of PAR-2 by tryptase on the cell signaling and proliferation of DLD-1, a human colon carcinoma cell line. PAR-2 stimulation by tryptase induced the increase in [Ca 2+ ] i , which was desensitized by the prior application of PAR-2 activating peptide (AP). The proliferative responses of DLD-1 to tryptase and PAR-2 AP were associated with the phosphorylation of MEK and MAP kinase. Inhibition of MEK by PD98059 completely inhibited the proliferationenhancing effects of tryptase and PAR-2 AP as well as phosphorylation of MAP kinase. Moreover, tryptase and PAR-2 AP stimulated the production of prostaglandin E 2 and the inhibition of prostaglandin synthesis by indomethacin or NS398 resulted in the complete inhibition of the proliferative responses to tryptase and PAR-2 AP. Furthermore, the tryptase-stimulated proliferation of DLD-1 was concentration-dependently inhibited by nafamostat mesilate, a specific inhi
Who reads Mast Cell Tryptase Stimulates DLD-1 Carcinoma Through Prostaglandin- and MAP Kinase-Dependent Manners?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Masanori Yoshii; Atsushi Jikuhara; Shuji Mori; Hiromi Iwagaki; Hideo K. Takahashi; Masahiro Nishibori; Noriaki Tanaka
- Publisher
- Japanese Pharmacological Society
- Published
- 2005
- Language
- EN
- Field
- Medicine (Life Sciences)