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Prothrombin antigen levels in symptomatic and asymptomatic carriers of the 20210A prothrombin variant by Paolo Simioni; Daniela Tormene; Davide Manfrin; Sabrina Gavasso; Sonia Luni; Domenico Stocco; Antonio Girolami is a Medicine article available to read on EtoBox.

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A recently discovered variant in the prothrombin gene (20210A) has been found in approximately 5–10% of patients with venous thromboembolism. It has been shown that patients with this variant present with high levels of prothrombin in plasma and this is maintained to be the most likely mechanism by which the risk of thrombosis is increased. We have evaluated prothrombin antigen levels in 50 carriers of the 20210A allele and compared with non‐carriers. 327 subjects were subdivided according to deficiency status and previous thrombosis. 30 symptomatic and 20 asymptomatic carriers had increased mean prothrombin levels as compared to symptomatic (__n__ = 178) or asymptomatic (__n__ = 99) non‐carriers. The percentage of subjects with prothrombin levels above cut‐off values of 1.15 u/ml or 1.30 u/ml was significantly higher in carriers of the prothrombin variant as compared to non‐carriers, regardless of a previous thrombosis. However, among non‐carriers the percentage of those with prothrombin levels above cut‐off values was significantly higher in the group of symptomatic as compared to asymptomatic individuals. In conclusion, increased prothrombin antigen levels, as detected by a spec

Who reads Prothrombin antigen levels in symptomatic and asymptomatic carriers of the 20210A prothrombin variant?

Author

Paolo Simioni; Daniela Tormene; Davide Manfrin; Sabrina Gavasso; Sonia Luni; Domenico Stocco; Antonio Girolami

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)

Published

1998

Language

EN

Field

Medicine (Health Sciences)