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Interactions Between Temperature‐sensitive Hydrogel Microspheres and Granulocytes by Koji Achiha; Rika Ojima; Yuji Kasuya; Keiji Fujimoto; Haruma Kawaguchi is a Materials Science article available to read on EtoBox.

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## Abstract Poly(N‐isopropylacrylamide) (PNIPAM) has a low critical solution temperature (LCST) at 32°C in water and the hydrophilicity changes through the LCST. The microspheres whose surface was composed of PNIPAM exhibited phase transition behavior around 32°C. Therefore, the interactions between PNIPAM micropheres and granulocytes depended on the temperature. That is, the oxygen consumption and active oxygen production by cells in contact with PNIPAM‐containing microspheres and adhesion of the microspheres to the cell surface were more enhanced above the LCST of PNIPAM than below it, whereas no significant temperature dependence of cell–microspheres interaction was observed in nonthermosensitive microsphere systems. It was suggested that the function of cells could be controlled with temperature using the temperature‐sensitive microspheres.

Who reads Interactions Between Temperature‐sensitive Hydrogel Microspheres and Granulocytes?

Author

Koji Achiha; Rika Ojima; Yuji Kasuya; Keiji Fujimoto; Haruma Kawaguchi

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1042-7147)

Published

1995

Field

Materials Science (Physical Sciences)