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Nucleic acid delivery into skin for the treatment of skin disease: Proofs-of-concept, potential impact, and remaining challenges by Michael Zakrewsky; Sunny Kumar; Samir Mitragotri is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Nucleic acid delivery into skin for the treatment of skin disease: Proofs-of-concept, potential impact, and remaining challenges about?

Nucleic acids (NAs) hold significant potential for the treatment of several diseases. Topical delivery of NAs for the treatment of skin diseases is especially advantageous since it bypasses the challenges associated with systemic administration which suffers from enzymatic degradation, systemic toxicity and lack of targeting to skin. However, the skin's protective barrier function limits the delivery of NAs into skin after topical application. Here, we highlight strategies for enhancing delivery of NAs into skin, and provide evidence that translation of topical NA therapies could have a transformative impact on the treatment of skin diseases.

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Author

Michael Zakrewsky; Sunny Kumar; Samir Mitragotri

Publisher

Elsevier BV

Published

2015

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)