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Vitamin E succinate inhibits NF‐κB and prevents the development of a metastatic phenotype in prostate cancer cells: Implications for chemoprevention by Paul L. Crispen; Robert G. Uzzo; Konstantin Golovine; Peter Makhov; Alan Pollack; Eric M. Horwitz; Richard E. Greenberg; Vladimir M. Kolenko is a Medicine article available to read on EtoBox.

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## Abstract ## BACKGROUND NF‐κB and AP‐1 transcriptional factors contribute to the development and progression of prostate malignancy by regulating the expression of genes involved in proliferation, apoptosis, angiogenesis, and metastasis. ## METHODS NF‐κB and AP‐1 activities were examined by TransAm assay. Cytokines levels were assessed by ELISA. ICAM‐1 and gp130 expression was examined by flow cytometry. Cell adhesion was examined by the ability of cells to adhere to fibronectin‐coated plates. Cell viability was determined by propidium iodide staining. ## RESULTS Treatment with α‐tocopherol succinate (VES) inhibits NF‐κB but augments AP‐1 activity, reduces expression of IL‐6, IL‐8, and VEGF, suppresses cell adhesion, ICAM‐1 and gp130 expression in androgen‐independent PC‐3, DU‐145, and CA‐HPV‐10 cells. VES supplementation also decreases the expression of anti‐apoptotic XIAP and Bcl‐X~L~ proteins and sensitizes androgen‐dependent LNCaP cells to androgen deprivation. ## CONCLUSIONS Our findings propose a potential mechanism of VES‐mediated anti‐tumor activity and support the role of vitamin E analogs as potential chemopreventative agents against prostate cancer. Prostate 67: 582–59

Who reads Vitamin E succinate inhibits NF‐κB and prevents the development of a metastatic phenotype in prostate cancer cells: Implications for chemoprevention?

Author

Paul L. Crispen; Robert G. Uzzo; Konstantin Golovine; Peter Makhov; Alan Pollack; Eric M. Horwitz; Richard E. Greenberg; Vladimir M. Kolenko

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)

Published

2007

Language

EN

Field

Medicine (Health Sciences)