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Valganciclovir Dosing for Cytomegalovirus Prophylaxis in Solid-organ Transplant Recipients on Continuous Veno-venous Hemodialysis by Andrew S Jarrell; Jessica R Crow; Sara E Strout; Rachel M Kruer; Lindsey P Toman; Maria V Dioverti-Prono; Laura Lees; Robin K Avery; Mark A Marzinke is a Medicine article available to read on EtoBox.
What is Valganciclovir Dosing for Cytomegalovirus Prophylaxis in Solid-organ Transplant Recipients on Continuous Veno-venous Hemodialysis about?
## Abstract ## Background Optimal valganciclovir dosing for cytomegalovirus (CMV) prophylaxis in solid-organ transplant (SOT) patients on continuous veno-venous hemodialysis (CVVHD) is not known. Ganciclovir trough concentrations ≥0.60 μg/mL have been suggested for CMV prophylaxis. This study was conducted to determine if valganciclovir 450 mg enterally every 24 hours achieves ganciclovir trough concentrations ≥0.60 μg/mL in patients on CVVHD. ## Methods This single-center, prospective, open-label, pharmacokinetic study included adult SOT patients admitted to an intensive care unit from March 2018 to June 2019 on CVVHD. All patients were receiving valganciclovir 450 mg enterally every 24 hours for CMV prophylaxis prior to enrollment. Each patient had a peak and trough sample drawn at steady state. ## Results Ten SOT patients were included in the study (6 liver, 1 simultaneous liver-kidney, 2 bilateral lung, 1 heart). The mean ± SD age was 51.8 ± 14.0 years, and average body mass index was 27 ± 6.9 kg/m2. Ganciclovir trough concentrations ranged from 0.31 to 3.16 μg/mL, and 80% of participants have trough concentrations ≥0.60 μg/mL. No patients had documented neutropenia while on va
Who reads Valganciclovir Dosing for Cytomegalovirus Prophylaxis in Solid-organ Transplant Recipients on Continuous Veno-venous Hemodialysis?
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- Author
- Andrew S Jarrell; Jessica R Crow; Sara E Strout; Rachel M Kruer; Lindsey P Toman; Maria V Dioverti-Prono; Laura Lees; Robin K Avery; Mark A Marzinke
- Publisher
- University of Chicago Press; Oxford University Press; Oxford University Press (OUP); American Astronomical Society (ISSN 1058-4838)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)