Opening book details…
Can I read Association of Immune-related Adverse Events Induced by Nivolumab with a Battery of Autoantibodies on EtoBox?
Association of Immune-related Adverse Events Induced by Nivolumab with a Battery of Autoantibodies by Iñigo Les; Mireia Martínez; Alicia Narro; Inés Pérez; Cristina Sánchez; Laura Puntí; Pilar Anaut; Saioa Eguiluz; Alberto Herrera; Severina Domínguez is a Medicine article available to read on EtoBox.
What is Association of Immune-related Adverse Events Induced by Nivolumab with a Battery of Autoantibodies about?
## Abstract ## Background The aim of this study was to assess the diagnostic performance of an autoantibody battery in patients receiving immune checkpoint inhibitors who experienced immune-related adverse events (irAEs). ## Methods We retrospectively analyzed several variables potentially related to irAEs, namely, demographic, clinical, and laboratory characteristics, including an autoantibody battery (antinuclear, anti-neutrophil cytoplasmic, anti-thyroid antibodies and rheumatoid factor). ## Results Sixty-nine patients (48 men; 61.8 ± 10.9 years at baseline) diagnosed with stage-4 solid-organ cancer and treated with nivolumab were followed up for 12 ± 10.3 months. Thirty-two irAEs were detected in 26 patients (37.5%). Adverse events occurred more commonly in women (62% vs. 27%, __p__ = .006), and younger patients (irAEs: 58.1 ± 9.8, no irAEs: 64.1 ± 10.9 years, __p__ = .024). Autoantibody battery results were available for 26 patients and were more frequently positive in patients with irAEs (87% vs. 30%, __p__ = .009). The positive predictive value, negative predictive value, and diagnostic accuracy of the battery were 82.3%, 77.8%, and 80.8%, respectively. Among the 64 patients
Who reads Association of Immune-related Adverse Events Induced by Nivolumab with a Battery of Autoantibodies?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Iñigo Les; Mireia Martínez; Alicia Narro; Inés Pérez; Cristina Sánchez; Laura Puntí; Pilar Anaut; Saioa Eguiluz; Alberto Herrera; Severina Domínguez
- Publisher
- Informa UK Limited
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)