Can I read Challenges in Constructing Genetic Instruments for Pharmacologic Therapies on EtoBox?

Challenges in Constructing Genetic Instruments for Pharmacologic Therapies by Ference, B. A.; Smith, G. Davey; Holmes, M. V.; Catapano, A. L.; Ray, K. K.; Nicholls, S. J. is a scholarly article available to read on EtoBox.

What is Challenges in Constructing Genetic Instruments for Pharmacologic Therapies about?

The genes that encode the targets of most therapies do not have rare variants with large-effect or common variants with moderate effects on the biomarker reflecting the pharmacologic action of the corresponding therapy. Therefore, providing genetic target validation for most therapies is challenging. Novel methods are being developed to combine multiple variants in the gene encoding the target of a therapy that are weakly associated with the biomarker reflecting the pharmacologic action of that therapy into a genetic score that can be used as an adequate instrumental variable. We describe one approach to solve this important problem.

Author

Ference, B. A.; Smith, G. Davey; Holmes, M. V.; Catapano, A. L.; Ray, K. K.; Nicholls, S. J.

Published

2020

Language

EN