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Liver Toxicity of Intravenous Heparin Treatment in Patients with Acute Ischemic Stroke by Yuki Yasutaka; Shinsuke Fujioka; Yoshio Tsuboi; Kohei Oyabu; Hirotomo Shibaguchi; Hidetoshi Kamimura is a Medicine article available to read on EtoBox.

What is Liver Toxicity of Intravenous Heparin Treatment in Patients with Acute Ischemic Stroke about?

Objective Serum alanine aminotransferase (ALT), which is an indicator of liver dysfunction, may increase during treatment in patients in the acute phase of stroke. However, the cause of the ALT elevation is unclear, as multiple medications are often being used. We investigated the relationship between medications used in acute ischemic stroke, including cerebral infarction and transient ischemic attack, and ALT elevation. Methods The subjects were 230 patients who had been diagnosed with cerebral infarction or TIA and treated at the Stroke Care Unit of Fukuoka University Hospital. We investigated ALT abnormalities that occurred from the start of the treatment over the subsequent 14 days. We also followed patients for an additional seven days to confirm the peak ALT levels. A binomial logistic regression analysis was performed to evaluate the association between medications used during the period and ALT elevation. Results The incidence of ALT abnormality was 23.9% (55/230). ALT elevation was mostly mild and peaked within 21 days of treatment initiation in 93.2% of the patients, excluding indeterminate patients. A binary logistic regression analysis showed that unfractionated hepari

Who reads Liver Toxicity of Intravenous Heparin Treatment in Patients with Acute Ischemic Stroke?

Author

Yuki Yasutaka; Shinsuke Fujioka; Yoshio Tsuboi; Kohei Oyabu; Hirotomo Shibaguchi; Hidetoshi Kamimura

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)