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Prolonged Seizures Recruit Caudal Subventricular Zone Glial Progenitors Into the Injured Hippocampus by Jack M. Parent; Nicolas von dem Bussche; Daniel H. Lowenstein is a Neuroscience article available to read on EtoBox.

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## Abstract Neurogenesis persists in the adult rat rostral forebrain subventricular zone (SVZ) and is stimulated by status epilepticus (SE). More caudal SVZ (cSVZ) neural progenitors migrate to the hippocampus after ischemic injury and contribute to CA1 pyramidal cell regeneration. Because SE also damages the hippocampus, we examined the effects of SE on cSVZ precursors. SE was induced in adult rats with pilocarpine, and cell proliferation in cSVZ and hippocampus was examined by bromodeoxyuridine (BrdU) and retroviral reporter labeling. Neural precursors were assayed by immunostaining for specfic markers between 1 and 35 days after SE. BrdU‐positive cells labeled prior to SE markedly increased in numbers within 1–2 weeks in the cSVZ and infracallosal region, but not in the corpus callosum. Doublecortin‐, polysialic acid neural cell adhesion molecule‐, and TUC‐4 (TOAD/Ulip/CRMP family‐4)‐immunostained cells with migrating morphology increased with a similar time course after SE and extended from the cSVZ to CA1 and CA3 regions. Retroviral reporters injected into the cSVZ of controls showed labeled cells with oligodendroglial morphology located in the cSVZ and corpus callosum; when i

Who reads Prolonged Seizures Recruit Caudal Subventricular Zone Glial Progenitors Into the Injured Hippocampus?

Author

Jack M. Parent; Nicolas von dem Bussche; Daniel H. Lowenstein

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1050-9631)

Published

2006

Language

EN

Field

Neuroscience (Life Sciences)