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Coma in Fatal Adult Human Malaria Is Not Caused by Cerebral Oedema by Isabelle M Medana; Nicholas PJ Day; Navakanit Sachanonta; Nguyen TH Mai; Arjen M Dondorp; Emsri Pongponratn; Tran T Hien; Nicholas J White; Gareth DH Turner is a Medicine article available to read on EtoBox.
What is Coma in Fatal Adult Human Malaria Is Not Caused by Cerebral Oedema about?
## Background The role of brain oedema in the pathophysiology of cerebral malaria is controversial. Coma associated with severe __Plasmodium falciparum__ malaria is multifactorial, but associated with histological evidence of parasitized erythrocyte sequestration and resultant microvascular congestion in cerebral vessels. To determine whether these changes cause breakdown of the blood-brain barrier and resultant perivascular or parenchymal cerebral oedema, histology, immunohistochemistry and image analysis were used to define the prevalence of histological patterns of oedema and the expression of specific molecular pathways involved in water balance in the brain in adults with fatal falciparum malaria. ## Methods The brains of 20 adult Vietnamese patients who died of severe malaria were examined for evidence of disrupted vascular integrity. Immunohistochemistry and image analysis was performed on brainstem sections for activation of the vascular endothelial growth factor (VEGF) receptor 2 and expression of the aquaporin 4 (AQP4) water channel protein. Fibrinogen immunostaining was assessed as evidence of blood-brain barrier leakage and perivascular oedema formation. Correlations we
Who reads Coma in Fatal Adult Human Malaria Is Not Caused by Cerebral Oedema?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Isabelle M Medana; Nicholas PJ Day; Navakanit Sachanonta; Nguyen TH Mai; Arjen M Dondorp; Emsri Pongponratn; Tran T Hien; Nicholas J White; Gareth DH Turner
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2002-; Springer Science and Business Media LLC; Research Square (ISSN 1475-2875)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)