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No evidence for systemic oxidant stress in Parkinson's or Alzheimer's disease by Dr. J. Eric Ahlskog; Ryan J. Uitti; Phillip A. Low; Gertrude M. Tyce; Kim K. Nickander; Ronald C. Petersen; Emre Kokmen is a Medicine article available to read on EtoBox.

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## Abstract Oxidant stress secondary to dopamine metabolism has been proposed as a pathogenic factor in the development of Parkinson's disease. Biochemical abnormalities extending beyond the central nervous system have been identified in patients with this condition. Previous investigators have found abnormally elevated concentrations of the lipid peroxidation product, malondialdehyde, in the plasma and serum of patients with Parkinson's disease. We attempted to replicate these findings but controlled for other factors that could influence malondialdehyde levels. We detected no significant elevations in mean serum malondialdehyde concentrations in either levodopatreated or untreated patients with Parkinson's disease, compared to normal controls; similarly, no elevation was found in a group of patients with dementia of Alzheimer's type. On the other hand, a group of subjects with diabetes mellitus but no neurodegenerative disease had significantly elevated mean serum malondialdehyde levels, consistent with previous studies of diabetic patients. Autoxidation is one of the two major routes by which dopamine and dopa metabolism may generate oxygen free radicals. We analyzed the autoxid

Who reads No evidence for systemic oxidant stress in Parkinson's or Alzheimer's disease?

Author

Dr. J. Eric Ahlskog; Ryan J. Uitti; Phillip A. Low; Gertrude M. Tyce; Kim K. Nickander; Ronald C. Petersen; Emre Kokmen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)

Published

1995

Language

EN

Field

Medicine (Health Sciences)