Can I read Involvement of NRON and TUG1 long noncoding RNAs in inflammation and the pathogenesis of EAE on EtoBox?

Involvement of NRON and TUG1 long noncoding RNAs in inflammation and the pathogenesis of EAE by Emad Kioumarsi; Leila Kohan; Farshid Noorbakhsh; Sadegh Shirian; Ali Gorji; Ameneh Zare-Chahoki is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Involvement of NRON and TUG1 long noncoding RNAs in inflammation and the pathogenesis of EAE about?

There is growing evidence that the long noncoding RNAs (lncRNAs) contribute to the pathogenesis of various neurodegenerative diseases such as multiple sclerosis (MS). The role of lncRNAs nuclear repressor of NFAT (NRON) and Taurine up-regulated 1 (TUG1) in the inflammatory processes occurring in the experimental autoimmune encephalomyelitis (EAE) model of MS is yet to be investigated. Transcript levels of NRON and TUG1 in acute and chronic phases of EAE and cultured macrophages as well as the correlation between NRON and TUG1 expression with inflammatory cytokines, were evaluated in this study. EAE experimental model was induced in female C57BL/6 mice with subcutaneous injection of MOG 35-55/ CFA. Mice were scored for 28 days and then sacrificed. The expression of lncRNAs TUG1 and NRON in lumbar spinal cords, activated and controlled macrophages as well as the expression of IL-1, IL-6, and CDe-3 inflammatory cytokines, were assayed by real-time RT-PCR. The lncRNAs TUG1 and NRON were significantly down-regulated in lumbar spinal cords tissues in the acute phase of EAE compared to the control group. TUG1 and NRON were significantly down-regulated in macrophages treated with 10 ng lip

Who reads Involvement of NRON and TUG1 long noncoding RNAs in inflammation and the pathogenesis of EAE?

Author

Emad Kioumarsi; Leila Kohan; Farshid Noorbakhsh; Sadegh Shirian; Ali Gorji; Ameneh Zare-Chahoki

Publisher

Informa UK Limited

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)