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What is RyhB Homologs in Yersinia pestis Stability about?

This document summarizes a study that characterized two small RNA (sRNA) homologs of RyhB (RyhB1 and RyhB2) in Yersinia pestis. The study found that both RyhB homologs are negatively regulated by the ferric uptake regulator Fur and have a half-life of over 30 minutes. RyhB1 stability requires the RNA-binding protein Hfq, while RyhB2 retains stability in the absence of Hfq. Both RyhB homologs were upregulated in mouse lungs infected with Y. pestis. Deletion of the ryhB gene had no effect on virulence in mice

Author

Diego Tulcan

Language

EN