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RBC antibody persistence by Henk Schonewille; Hans L. Haak; Annette M. Van Zijl is a Medicine article available to read on EtoBox.

What is RBC antibody persistence about?

**BACKGROUND:** A person exposed to foreign blood group antigens may produce antibodies. The persistence of antibodies varies among people and among antibodies. A study was performed to investigate the persistence of clinically significant RBC alloantibodies over a period of 20 years. **STUDY DESIGN AND METHODS:** A retrospective examination was performed of all records of RBC antibodies in the transfusion laboratory computer database from 1978 through 1997. Records of patients who underwent at least one antibody investigation after an antibody had been detected were studied. The study included all antibodies against the Rh, K, Fy, Jk, and MNs blood group systems. An antibody was regarded as not persistent if, after previous detection, the screening or panel studies became negative for the antibody under study. Anti‐D due to RhIg administration was excluded. **RESULTS:** An analysis was performed of 480 records consisting of 593 antibodies that fulfilled the criteria. Median antibody follow‐up was 10 months (range, 1‐240). In 137 patients, 153 (26%) antibodies became undetectable over the course of time. After initial negative screening investigations, 310 antibodies were formed. T

Who reads RBC antibody persistence?

Author

Henk Schonewille; Hans L. Haak; Annette M. Van Zijl

Publisher

Elsevier Science; John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Elsevier; Elsevier BV; Wiley (ISSN 0372-1248)

Published

2000

Language

EN

Field

Medicine (Health Sciences)