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027 Protein cargo of plasma-derived extracellular vesicles drives innate mediated inflammation in dermatomyositis by A. Baniel; M. Ogawa-Momohara; P. Rachita; J. Kleitsch; M. Liu; V.P. Werth is a Medicine article available to read on EtoBox.

What is 027 Protein cargo of plasma-derived extracellular vesicles drives innate mediated inflammation in dermatomyositis about?

Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis is characterized by amyopathic DM with interstitial lung disease (ILD). Here, we investigated whether autoimmunity against MDA5 has a pathological role in the development of ILD. C57BL/6 mice were immunized with emulsion including recombinant mouse MDA5 whole protein once a week for 4 times. The MDA5-immunized mice were intranasally administrated with polyinosinic-polycytidylic acid [poly (I:C)] at the same time of the last immunization. MDA5-reactive T cells and anti-MDA5 antibodies were developed in the MDA5-immunizd mice, which developed ILD-like disease consisting of respiratory CD4 + T cell-rich inflammatory cell infiltration and fibrotic changes at day 35, while no control mice did (P < 0.01 by Fisher's exact test). The contents of collagen of the lungs were also upregulated in the MDA5-

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Author

A. Baniel; M. Ogawa-Momohara; P. Rachita; J. Kleitsch; M. Liu; V.P. Werth

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)