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Prenatal lead exposure and fetal growth: Smaller infants have heightened susceptibility by Rodosthenis S. Rodosthenous; Heather H. Burris; Katherine Svensson; Chitra J. Amarasiriwardena; Alejandra Cantoral; Lourdes Schnaas; Adriana Mercado-García; Brent A. Coull; Robert O. Wright; Martha M. Téllez-Rojo; Andrea A. Baccarelli is a Environmental Science article available to read on EtoBox.

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## Background: As population lead levels decrease, the toxic effects of lead may be distributed to more sensitive populations, such as infants with poor fetal growth. ## Objectives: To determine the association of prenatal lead exposure and fetal growth; and to evaluate whether infants with poor fetal growth are more susceptible to lead toxicity than those with normal fetal growth. ## Methods: We examined the association of second trimester maternal blood lead levels (bll) with birthweight-for-gestational age (bwga) z-score in 944 mother-infant participants of the progress cohort. we determined the association between maternal bll and bwga z-score by using both linear and quantile regression. we estimated odds ratios for small-for-gestational age (sga) infants between maternal bll quartiles using logistic regression. maternal age, body mass index, socioeconomic status, parity, household smoking exposure, hemoglobin levels, and infant sex were included as confounders. ## Results: While linear regression showed a negative association between maternal bll and bwga z-score (β=-0.06 z-score units per log bll increase; 95% ci: -0.13, 0.003; p=0.06), quantile regression revealed larger ma

Who reads Prenatal lead exposure and fetal growth: Smaller infants have heightened susceptibility?

Author

Rodosthenis S. Rodosthenous; Heather H. Burris; Katherine Svensson; Chitra J. Amarasiriwardena; Alejandra Cantoral; Lourdes Schnaas; Adriana Mercado-García; Brent A. Coull; Robert O. Wright; Martha M. Téllez-Rojo; Andrea A. Baccarelli

Publisher

Elsevier BV

Published

2016

Language

EN

Field

Environmental Science (Physical Sciences)