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Detection of Vascular Endothelial Growth Factor and Its Receptor Expression in Human Hepatocellular Carcinoma Biopsy Specimens by Takeshi Shimamura; Satoru Saito; Katsumi Morita; Takehiko Kitamura; Manabu Morimoto; Takayoshi Kiba; Kazushi Numata; Katsuaki Tanaka; Hisahiko Sekihara is a Medicine article available to read on EtoBox.
What is Detection of Vascular Endothelial Growth Factor and Its Receptor Expression in Human Hepatocellular Carcinoma Biopsy Specimens about?
## Abstract **__Background__**: Vascular endothelial growth factor (VEGF) exerts its actions on the microvasculature, by interacting with specific endothelial cell receptors, and thus, contributes to angiogenesis and growth in many tumours. **__Methods__**: Using nested reverse‐transcription–polymerase chain reaction, we examined the biopsy specimens of 14 patients with human hepatocellular carcinoma (HCC) and cirrhosis, for the expression of hepatic VEGF, and the VEGF receptors KDR and flt‐1. To avoid the influence of hypoxia or ischaemia induced by surgical manipulation, we used biopsy specimens of the liver instead of resected specimens. **__Results__**: Vascular endothelial growth factor mRNA expression was detected in the tumour portion of the specimens in 13 of 14 patients (93%), and in the corresponding non‐tumour portion of the specimens in eight patients (57%; __P__ = 0.08). No differences were found between the tumour portion and the corresponding non‐tumour portion in relative concentrations of VEGF mRNA. However, mRNA expression of the VEGF receptors, KDR and flt‐1, was detected in 14 (100%) and 11 (79%) of the tumour portions, respectively, and in four (29%) and five (
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- Author
- Takeshi Shimamura; Satoru Saito; Katsumi Morita; Takehiko Kitamura; Manabu Morimoto; Takayoshi Kiba; Kazushi Numata; Katsuaki Tanaka; Hisahiko Sekihara
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0815-9319)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)