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Efficacy and safety of pharmacotherapy for Alzheimer’s disease and for behavioural and psychological symptoms of dementia in older patients with moderate and severe functional impairments: a systematic review of controlled trials by Seibert, M. (author);Mühlbauer, V. (author);Holbrook, J. (author);Voigt-Radloff, S. (author);Brefka, S. (author);Dallmeier, D. (author);Denkinger, M. (author);Schönfeldt-Lecuona, C. (author);Klöppel, S. (author);von Arnim, C. A. F. (author) is a Medicine article available to read on EtoBox.

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## Background Many patients with Alzheimer’s disease (AD) are physically frail or have substantial functional impairments. There is growing evidence that such patients are at higher risk for medication-induced adverse events. Furthermore, frailty seems to be more predictive of poor clinical outcomes than chronological age alone. To our knowledge, no systematic review of clinical trials examining drug therapy of AD or behavioural and psychological symptoms of dementia (BPSD) has specifically focused on the topic of physical frailty. Our objective was to evaluate the efficacy and safety of pharmacotherapy in AD patients with frailty or significant functional impairments. ## Methods We performed a systematic literature search in MEDLINE, Embase and the Cochrane Central Register of Controlled Trials (CENTRAL) for randomized controlled trials (RCTs) of drug therapy of AD and BPSD in patients with significant functional impairments according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and Cochrane research criteria. Significant functionally impaired patient populations were identified using the recommendations of the Medication and Quality

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Author

Seibert, M. (author);Mühlbauer, V. (author);Holbrook, J. (author);Voigt-Radloff, S. (author);Brefka, S. (author);Dallmeier, D. (author);Denkinger, M. (author);Schönfeldt-Lecuona, C. (author);Klöppel, S. (author);von Arnim, C. A. F. (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)