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Optimization of the dosing regimen of mycophenolate mofetil in pediatric liver transplant recipients: Mycophenolic Acid in Pediatric Transplantation by Caroline Barau; Aurélie Barrail-Tran; Bogdan Hemerziu; Dalila Habes; Anne-Marie Taburet; Dominique Debray; Valérie Furlan is a Medicine article available to read on EtoBox.
What is Optimization of the dosing regimen of mycophenolate mofetil in pediatric liver transplant recipients: Mycophenolic Acid in Pediatric Transplantation about?
Mycophenolate mofetil (MMF) is now commonly used in pediatric liver transplant recipients, but no clear recommendations about the dosing regimen have been made for this population. The aim of this study was to determine the MMF dosage required for pediatric liver transplant recipients to achieve an area under the plasma concentration-time curve from 0 to 12 hours (AUC 0-12 ) for mycophenolic acid (MPA) greater than 30 mg hour/L. A pharmacokinetic study of 15 children (median age 1⁄4 8.3 years, range 1⁄4 1.1-15.2 years) was performed at a median of 11.0 months (range 1⁄4 0.5-88.0 months) after liver transplantation. MMF was initially introduced at a median starting dose of 300 mg/m 2 twice a day (range 1⁄4 186-554 mg/m 2 twice a day). Thirteen of the 15 patients had an MPA AUC 0-12 value less than 30 mg hour/L. The MMF dosage had to be increased in all patients except 1. The MMF dosage required to reach an MPA AUC 0-12 value greater than the defined target of 30 mg hour/L ranged from 371 to 1014 mg/m 2 /day. For 2 patients who received rifampin in addition to MMF, the MPA AUC 0-12 value remained low despite a 2-fold increase in the MMF dosage. In conclusion, an initial MMF dose of 6
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- Author
- Caroline Barau; Aurélie Barrail-Tran; Bogdan Hemerziu; Dalila Habes; Anne-Marie Taburet; Dominique Debray; Valérie Furlan
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)