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Can I read Circulating MiRNA-21-enriched extracellular vesicles promote bone remodeling in traumatic brain injury patients on EtoBox?
Circulating MiRNA-21-enriched extracellular vesicles promote bone remodeling in traumatic brain injury patients by Ze Lin; Yuan Xiong; Yun Sun; Ruiyin Zeng; Hang Xue; Yiqiang Hu; Lang Chen; Guodong Liu; Adriana C. Panayi; Wu Zhou; Faqi Cao; Fei Gao; Bobin Mi; Guohui Liu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Circulating MiRNA-21-enriched extracellular vesicles promote bone remodeling in traumatic brain injury patients about?
Fracture combined with traumatic brain injury (TBI) is one of the most common and serious types of compound trauma in the clinic and is characterized by dysfunction of cellular communication in injured organs. Our prior studies found that TBI was capable of enhancing fracture healing in a paracrine manner. Exosomes (Exos), as small extracellular vesicles, are important paracrine vehicles for noncell therapy. However, whether circulating Exos derived from TBI patients (TBI-Exos) regulate the prohealing effects of fractures remains unclear. Thus, the present study aimed to explore the biological effects of TBI-Exos on fracture healing and reveal the potential molecular mechanism. TBI-Exos were isolated by ultracentrifugation, and the enriched miR-21-5 p was identified by qRT‒PCR analysis. The beneficial effects of TBI-Exos on osteoblastic differentiation and bone remodeling were determined by a series of in vitro assays. Bioinformatics analyses were conducted to identify the potential downstream mechanisms of the regulatory effect of TBI-Exos on osteoblasts. Furthermore, the role of the potential signaling pathway of TBI-Exos in mediating the osteoblastic activity of osteoblasts was
Who reads Circulating MiRNA-21-enriched extracellular vesicles promote bone remodeling in traumatic brain injury patients?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ze Lin; Yuan Xiong; Yun Sun; Ruiyin Zeng; Hang Xue; Yiqiang Hu; Lang Chen; Guodong Liu; Adriana C. Panayi; Wu Zhou; Faqi Cao; Fei Gao; Bobin Mi; Guohui Liu
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)