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NAMPT mitigates colitis severity by supporting redox-sensitive activation of phagocytosis in inflammatory macrophages by Sun Mi Hong; A-Yeon Lee; Sung-Min Hwang; Yu-Jin Ha; Moo-Jin Kim; Seongki Min; Won Hwang; Gyesoon Yoon; So Mee Kwon; Hyun Goo Woo; Hee-Hoon Kim; Won-Il Jeong; Han-Ming Shen; Sin-Hyeog Im; Dakeun Lee; You-Sun Kim is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is NAMPT mitigates colitis severity by supporting redox-sensitive activation of phagocytosis in inflammatory macrophages about?
Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the nicotinamide adenine dinucleotide (NAD^+^) salvage pathway and plays a crucial role in the maintenance of the NAD^+^ pool during inflammation. Considering that macrophages are essential for tissue homeostasis and inflammation, we sought to examine the functional impact of NAMPT in inflammatory macrophages, particularly in the context of inflammatory bowel disease (IBD). In this study, we show that mice with NAMPT deletion within the myeloid compartment (__Nampt__^__f/f__^__LysMCre__^__+/-__^__, Nampt__ mKO) have more pronounced colitis with lower survival rates, as well as numerous uncleared apoptotic corpses within the mucosal layer. __Nampt__-deficient macrophages exhibit reduced phagocytic activity due to insufficient NAD^+^ abundance, which is required to produce NADPH for the oxidative burst. Nicotinamide mononucleotide (NMN) treatment rescues NADPH levels in __Nampt__ mKO macrophages and sustains superoxide generation via NADPH oxidase. Consequently, __Nampt__ mKO mice fail to clear dead cells during tissue repair, leading to substantially prolonged chronic colitis. Moreover, systemic administra
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It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Sun Mi Hong; A-Yeon Lee; Sung-Min Hwang; Yu-Jin Ha; Moo-Jin Kim; Seongki Min; Won Hwang; Gyesoon Yoon; So Mee Kwon; Hyun Goo Woo; Hee-Hoon Kim; Won-Il Jeong; Han-Ming Shen; Sin-Hyeog Im; Dakeun Lee; You-Sun Kim
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)