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Effects of Verbascoside, a Phenylpropanoid Glycoside from Lemon Verbena, on Phospholipid Model Membranes by Lorena Funes; Olga Laporta; Manuela Cerdán-Calero; Vicente Micol is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Effects of Verbascoside, a Phenylpropanoid Glycoside from Lemon Verbena, on Phospholipid Model Membranes about?

Phenylpropanoid glycosides are water-soluble compounds widely distributed, most of them deriving from medicinal herbs. Among them, verbascoside or acteoside has exhibited a wide biological activity, being free radical scavenging the most representative one. Moreover, antitumor, antimicrobial, antiinflammatory, anti-thrombotic and wound healing properties have been previously described. Herein, the interaction of verbascoside with phospholipid membranes has been studied by means of differential scanning calorimetry, fluorescence anisotropy and dynamic light scattering. Verbascoside showed stronger affinity for negatively charged membranes composed of phosphatidylglycerol (PG) than for phosphatidylcholine (PC) membranes. This compound promoted phase separation of lipid domains in PC membranes and formed a stable lipid complex with and approximate phospholipid/verbascoside ratio of 4:1. Despite its hydrophilic character, verbascoside's caffeoyl moiety was located deep into the hydrophobic core of PC membranes and was almost inaccessible to spin probes located at different depths in PG membranes. This compound affected the ionization behavior of the PG phosphate group and most likely i

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Author

Lorena Funes; Olga Laporta; Manuela Cerdán-Calero; Vicente Micol

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-3084)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)