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Carboxylesterase 2 Proteins Are Efficient Diglyceride and Monoglyceride Lipases Possibly Implicated in Metabolic Disease by Gabriel Chalhoub; Stephanie Kolleritsch; Lisa K. Maresch; Ulrike Taschler; Laura Pajed; Anna Tilp; Helgit Eisner; Philipp Rosina; Benedikt Kien; Franz P.W. Radner; Rudolf Schicho; Monika Oberer; Gabriele Schoiswohl; Guenter Haemmerle is a Medicine article available to read on EtoBox.
What is Carboxylesterase 2 Proteins Are Efficient Diglyceride and Monoglyceride Lipases Possibly Implicated in Metabolic Disease about?
Carboxylesterase 2 (CES2/Ces2) proteins exert established roles in (pro)drug metabolism. Recently, human and murine CES2/Ces2c have been discovered as triglyceride (TG) hydrolases implicated in the development of obesity and fatty liver disease. The murine __Ces2__ family consists of seven homologous genes as opposed to a single __CES2__ gene in humans. However, the mechanistic role of Ces2 protein family members is not completely understood. In this study, we examined activities of all Ces2 members toward TGs, diglycerides (DGs), and monoglycerides (MGs) as the substrate. Besides CES2/Ces2c, we measured significant TG hydrolytic activities for Ces2a, Ces2b, and Ces2e. Notably, these Ces2 members and CES2 efficiently hydrolyzed DGs and MGs, and their activities even surpassed those measured for TG hydrolysis. The localization of CES2/Ces2c proteins at the ER may implicate a role of these lipases in lipid signaling pathways. We found divergent expression of __Ces2__ genes in the liver and intestine of mice on a high-fat diet, which could relate to changes in lipid signaling. Finally, we demonstrate reduced __CES2__ expression in the colon of patients with inflammatory bowel disease
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- Author
- Gabriel Chalhoub; Stephanie Kolleritsch; Lisa K. Maresch; Ulrike Taschler; Laura Pajed; Anna Tilp; Helgit Eisner; Philipp Rosina; Benedikt Kien; Franz P.W. Radner; Rudolf Schicho; Monika Oberer; Gabriele Schoiswohl; Guenter Haemmerle
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)