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Branching of Calyceal Afferents During Postnatal Development in the Rat Auditory Brainstem by Adrián Rodríguez-Contreras; Robert P.J. de Lange; Paul J. Lucassen; J. Gerard G. Borst is a Neuroscience article available to read on EtoBox.

What is Branching of Calyceal Afferents During Postnatal Development in the Rat Auditory Brainstem about?

## Abstract Cells in the anteroventral cochlear nucleus (aVCN) send out calyceal axons that form large excitatory somatic terminals, the calyces of Held, onto principal cells of the contralateral medial nucleus of the trapezoid body (MNTB). It is unclear which fraction of these axons might form more than one calyx and whether this fraction changes during development. We combined in vitro anterograde tracing, stereological cell counts, analysis of apoptosis, and immunohistochemistry to study the development of calyceal afferents in rats of different postnatal ages. We found that some principal cells were contacted by multiple large axosomatic inputs, but these invariably originated from the same axon. Conversely, at least 18% of traced afferents branched to form multiple calyces, independently of age. Calyces from the same axon generally innervated nearby principal cells, and most of these branch points were <50 μm away from the synaptic terminals. Our results show that the projection from the aVCN to the MNTB is divergent, both when calyces have just been formed and in the adult. Cell counts did not provide evidence for principal cell loss during development, although analysis of a

Who reads Branching of Calyceal Afferents During Postnatal Development in the Rat Auditory Brainstem?

Author

Adrián Rodríguez-Contreras; Robert P.J. de Lange; Paul J. Lucassen; J. Gerard G. Borst

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)

Published

2006

Language

EN

Field

Neuroscience (Life Sciences)