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What is VDJ Recombination in Ig and TCR Diversity about?

VDJ recombination generates antibody and T cell receptor diversity through rearrangement of gene segments. Variable (V), diversity (D), and joining (J) gene segments are brought together and joined through enzymatic cleavage and ligation. This process introduces insertions, deletions, and substitutions that result in a highly diverse repertoire of antigen receptors, with the most variability occurring in the third complementarity determining region encoded at V-D and V-J junctions. The key steps involve rec

Author

Adnan

Language

EN