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Serum-Based Lipid Panels for Diagnosis of Idiopathic Parkinson’s Disease by Lina A. Dahabiyeh; Refat M. Nimer; Maha Rashed; Jeremiah D. Wells; Oliver Fiehn is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Serum-Based Lipid Panels for Diagnosis of Idiopathic Parkinson’s Disease about?

Parkinson’s disease (PD) is a highly prevalent neurodegenerative movement disorder with an unclear etiology and a lack of definite diagnostic tests and effective treatments. About 95% of PD cases are idiopathic, in which none of the well-known genes underlying familial parkinsonism are mutated. We used untargeted liquid chromatography–mass spectrometry (LC-MS/MS) to profile the serum lipidome of 50 patients with different stages of idiopathic PD (early, mid, or advanced) and 45 age-matched controls. When comparing the PD patients to the control subjects, 169 lipids were significantly altered in both a univariate analysis and a multivariate partial least-squares discriminant analysis (PLS-DA). Compared to the controls, the patients with PD had higher levels of unsaturated triacylglycerides (e.g., TG O-56:9 and TG 52:3), saturated lysophosphatidylcholines (LPC 17:0, 16:0, and 15:0), and hydroxyeicosatetraenoic acid (12-HETE), while lower levels of phosphatidylserines (e.g., PS 40:4 and PS 16:0\_22:4), sphingomyelins (SM 42:1), and ceramides (e.g., Cer 40:0 and 42:0) were found between the PD patients and the controls. A panel of 10 significantly altered lipids (PS 40:0, Cer 40:0, Cer

Who reads Serum-Based Lipid Panels for Diagnosis of Idiopathic Parkinson’s Disease?

Author

Lina A. Dahabiyeh; Refat M. Nimer; Maha Rashed; Jeremiah D. Wells; Oliver Fiehn

Publisher

MDPI AG

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)