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Downregulation of Siah1 promotes colorectal cancer cell proliferation and migration by regulating AKT and YAP ubiquitylation and proteasome degradation by Xiao, Zhiyuan; Wei, Zhigang; Deng, Danling; Zheng, Zhe; Zhao, Yali; Jiang, Shenglu; Zhang, Dan; Zhang, Ling-Jie; Fan, Mingmei; Chen, Siqi; Wang, ShuYang; Ding, Yanqing; Ye, Yaping; Jiao, Hongli is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Downregulation of Siah1 promotes colorectal cancer cell proliferation and migration by regulating AKT and YAP ubiquitylation and proteasome degradation about?

## Background Colorectal cancer (CRC) is one of the most common malignant tumors in the world. Siah E3 ubiquitin protein ligase 1 (Siah1) has been identified as a tumor suppressor gene and plays an important role in the development of malignant tumors. However, the potential role and molecular mechanism of Siah1 in the development and progression of CRC is still unclear. ## Methods To explore the role and molecular mechanism of Siah1 in the development and progression of CRC, we examined the expression of Siah1 in CRC tissue samples and analyzed its association with progression and prognosis in CRC. In addition, overexpression and knockdown of Siah1 was used to investigate its activity in CRC cells. We also use bioinformatics to analyze and verify the significant roles of Siah1 in critical signaling pathways of CRC. ## Results We found that the expression of Siah1 was significantly downregulated in CRC tissues, and low expression of Siah1 was associated with aggressive TNM staging and poor survival of CRC patients. Moreover, we revealed that overexpression of Siah1 in CRC cells markedly inhibited CRC cell proliferation and invasion in vitro and in vivo, while knockdown of Siah1 enh

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Author

Xiao, Zhiyuan; Wei, Zhigang; Deng, Danling; Zheng, Zhe; Zhao, Yali; Jiang, Shenglu; Zhang, Dan; Zhang, Ling-Jie; Fan, Mingmei; Chen, Siqi; Wang, ShuYang; Ding, Yanqing; Ye, Yaping; Jiao, Hongli

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC (ISSN 1475-2867)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)