Opening book details…
Can I read Synthesis and structure–activity relationships of a series of 3-aryl-4-isoxazolecarboxamides as a new class of TGR5 agonists on EtoBox?
Synthesis and structure–activity relationships of a series of 3-aryl-4-isoxazolecarboxamides as a new class of TGR5 agonists by Brian W. Budzik; Karen A. Evans; David D. Wisnoski; Jian Jin; Ralph A. Rivero; George R. Szewczyk; Channa Jayawickreme; David L. Moncol; Hongshi Yu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis and structure–activity relationships of a series of 3-aryl-4-isoxazolecarboxamides as a new class of TGR5 agonists about?
A series of 3-aryl-4-isoxazolecarboxamides identified from a high-throughput screening campaign as novel, potent agonists of the human TGR5 G-protein-coupled receptor is described. Many analogues were readily accessible via solution-phase synthesis which resulted in the rapid identification of key structure-activity relationships (SAR), and the discovery of potent exemplars (up to pEC50=9). Details of the SAR and optimization of this series are presented herein.
Who reads Synthesis and structure–activity relationships of a series of 3-aryl-4-isoxazolecarboxamides as a new class of TGR5 agonists?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Brian W. Budzik; Karen A. Evans; David D. Wisnoski; Jian Jin; Ralph A. Rivero; George R. Szewczyk; Channa Jayawickreme; David L. Moncol; Hongshi Yu
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2010
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)