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Enhancement of Therapies for Glioblastoma (GBM) Using Nanoparticle-based Delivery Systems by Kanawat Wiwatchaitawee; Juliana C. Quarterman; Sean M. Geary; Aliasger K. Salem is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

What is Enhancement of Therapies for Glioblastoma (GBM) Using Nanoparticle-based Delivery Systems about?

Glioblastoma multiforme (GBM) is the most aggressive type of malignant brain tumor. Current FDA-approved treatments include surgical resection, radiation, and chemotherapy, while hyperthermia, immunotherapy, and most relevantly, nanoparticle (NP)-mediated delivery systems or combinations thereof have shown promise in preclinical studies. Drug-carrying NPs are a promising approach to brain delivery as a result of their potential to facilitate the crossing of the blood-brain barrier (BBB) via two main types of transcytosis mechanisms: adsorptive-mediated transcytosis (AMT) and receptor-mediated transcytosis (RMT). Their ability to accumulate in the brain can thus provide local sustained release of tumoricidal drugs at or near the site of GBM tumors. NP-based drug delivery has the potential to significantly reduce drug-related toxicity, increase specificity, and consequently improve the lifespan and quality of life of patients with GBM. Due to significant advances in the understanding of the molecular etiology and pathology of GBM, the efficacy of drugs loaded into vectors targeting this disease has increased in both preclinical and clinical settings. Multitargeting NPs, such as those

Who reads Enhancement of Therapies for Glioblastoma (GBM) Using Nanoparticle-based Delivery Systems?

Author

Kanawat Wiwatchaitawee; Juliana C. Quarterman; Sean M. Geary; Aliasger K. Salem

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)