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The Role of Protein Corona on Nanodrugs for Organ-targeting and Its Prospects of Application by Sijie Wang; Junlei Zhang; Huanli Zhou; Yi Chao Lu; Xizhi Jin; Lihua Luo; Jian You is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is The Role of Protein Corona on Nanodrugs for Organ-targeting and Its Prospects of Application about?

Nowadays, nanodrugs become a hotspot in the high-end medical field. They have the ability to deliver drugs to reach their destination more effectively due to their unique properties and flexible functionalization. However, the fate of nanodrugs in vivo is not the same as those presented in vitro, which indeed influenced their therapeutic efficacy in vivo. When entering the biological organism, nanodrugs will first come into contact with biological fluids and then be covered by some biomacromolecules, especially proteins. The proteins adsorbed on the surface of nanodrugs are known as protein corona (PC), which causes the loss of prospective organ-targeting abilities. Fortunately, the reasonable utilization of PC may determine the organ-targeting efficiency of systemically administered nanodrugs based on the diverse expression of receptors on cells in different organs. In addition, the nanodrugs for local administration targeting diverse lesion sites will also form unique PC, which plays an important role in the therapeutic effect of nanodrugs. This article introduced the formation of PC on the surface of nanodrugs and summarized the recent studies about the roles of diversified prot

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Author

Sijie Wang; Junlei Zhang; Huanli Zhou; Yi Chao Lu; Xizhi Jin; Lihua Luo; Jian You

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)