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Chemogenetics a Robust Approach to Pharmacology and Gene Therapy by Keifer, O.; Kambara, K.; Lau, A.; Makinson, S.; Bertrand, D. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Chemogenetics a Robust Approach to Pharmacology and Gene Therapy about?

Modern developments in organic chemistry, molecular biology, virology, and genetics have opened new, exciting possibilities to better understand physiology and to create innovative, robust therapeutics. One such possibility is the burgeoning field of chemogenetics, a sub-field of chemical genetics that encompasses engineering macromolecules (particularly proteins) to modify how they interact with endogenous and exogenous ligands (particularly small molecules). Early efforts in chemogenetics were focused on parsing the function of a specific enzyme within a closely-related family by creating orthogonal enzyme-ligand pairs (e.g. kinases paired with antagonists). This powerful concept quickly expanded into engineered G-protein-coupled receptors (e.g. DREADDs/RASSL), and more recently into engineered ligand-gated ion channels (eLGIC). The modifications to the receptor focused on eliminating their activation by endogenous ligands, while preserving or enhancing their interaction with pharmacological agents (e.g. small molecule agonist). Creation of such an engineered receptor and delivering it selectively to specific cell types opens new possibilities of accurately and precisely controll

Who reads Chemogenetics a Robust Approach to Pharmacology and Gene Therapy?

Author

Keifer, O.; Kambara, K.; Lau, A.; Makinson, S.; Bertrand, D.

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0006-2952)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)