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Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia by Kajsa Paulsson; Andrea Horvat; Bodil Strömbeck; Fredrik Nilsson; Jesper Heldrup; Mikael Behrendtz; Erik Forestier; Anna Andersson; Thoas Fioretos; Bertil Johansson is a Medicine article available to read on EtoBox.

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## Abstract Although it has been suggested that mutations of the __FLT3__, __NRAS__, __KRAS__, and __PTPN11__ genes are particularly frequent in high hyperdiploid (>50 chromosomes) pediatric acute lymphoblastic leukemias (ALLs), this has as yet not been confirmed in a large patient cohort. Furthermore, it is unknown whether mutations of these genes coexist in hyperdiploid cases. We performed mutation analyses of __FLT3__, __NRAS__, __KRAS__, and __PTPN11__ in a consecutive series of 78 high hyperdiploid ALLs. Twenty‐six (33%) of the cases harbored a mutation, comprising six activating point mutations and one internal tandem duplication of __FLT3__ (7/78 cases; 9.0%), eight codon 12, 13, or 61 __NRAS__ mutations (8/78 cases; 10%), five codon 12 or 13 __KRAS__ mutations (5/78 cases, 6.4%), and seven exon 3 or 13 __PTPN11__ mutations (7/78 cases; 9.0%). No association was seen between the presence of a mutation in __FLT3__, __NRAS__, __KRAS__, or __PTPN11__ and gender, age, white blood cell count, or relapse, suggesting that they do not confer a negative prognostic impact. Only one case harbored mutations in two different genes, suggesting that mutations of these four genes are genera

Who reads Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia?

Author

Kajsa Paulsson; Andrea Horvat; Bodil Strömbeck; Fredrik Nilsson; Jesper Heldrup; Mikael Behrendtz; Erik Forestier; Anna Andersson; Thoas Fioretos; Bertil Johansson

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)

Published

2007

Language

EN

Field

Medicine (Life Sciences)