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Real-world evaluation of effectiveness, persistence, and usage patterns of tofacitinib in treatment of rheumatoid arthritis in Australia by Bird, Paul; Littlejohn, Geoffrey; Butcher, Belinda; Smith, Tegan; da Fonseca Pereira, Candida; Witcombe, David; Griffiths, Hedley is a Medicine article available to read on EtoBox.
What is Real-world evaluation of effectiveness, persistence, and usage patterns of tofacitinib in treatment of rheumatoid arthritis in Australia about?
## Introduction: The aim of this study was to describe the real-world evidence for effectiveness, treatment persistence, and treatment patterns among patients in the community with rheumatoid arthritis treated with the jak inhibitor tofacitinib. ## Methods: This was a retrospective, non-interventional cohort study that extracted data for new users of tofacitinib or biologic disease-modifying antirheumatic drugs (bdmards) from the australian optimizing patient outcomes in australian rheumatology (opal) dataset between march 2015 and september 2018. patients were propensity score matched at a 1:2 tofacitinib to bdmard ratio based on age, sex, and selected baseline treatment combinations. treatment effectiveness was evaluated using disease status measures. treatment persistence was calculated and the percentage of patients receiving monotherapy or combination therapy at treatment initiation was evaluated. ## Results: Data from 2810 patients were extracted and 1950 patients were included in the matched population (1300 bdmard initiators and 650 tofacitinib initiators). patients were predominantly aged 55 to 74 years (57.8%) and female (81.2%). after 18 months of treatment, 52.4% and 57
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- Author
- Bird, Paul; Littlejohn, Geoffrey; Butcher, Belinda; Smith, Tegan; da Fonseca Pereira, Candida; Witcombe, David; Griffiths, Hedley
- Publisher
- Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0770-3198)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)